Against Bacterial Pathogens

O'Shea MK, Fletcher TE, Muller J, Tanner R, Matsumiya M, Bailey JW, Jones J, Smith SG, Koh G, Horsnell WG, Beeching NJ, Dunbar J, Wilson D, Cunningham AF, McShane H. Human Hookworm Infection Enhances Mycobacterial Growth Inhibition and Associates With Reduced Risk of Tuberculosis Infection. Front Immunol. 2018;9:2893. doi:10.3389/fimmu.2018.02893. PMC6302045.

Against Parasitic Pathogens

Gaze S, McSorley HJ, Daveson J, Jones D, Bethony JM, Oliveira LM, Speare R, McCarthy JS, Engwerda CR, Croese J, Loukas A. Characterising the Mucosal and Systemic Immune Responses to Experimental Human Hookworm Infection. PLoS Pathog. 2012;8(2):e1002520. doi:10.1371/journal.ppat.1002520.

Decrease Inflammation to Other Helminths Ferreira I, Smyth D, Gaze S, Aziz A, Giacomin P, Ruyssers N, Artis D, Laha T, Navarro S, Loukas A, McSorley HJ. Hookworm Excretory/Secretory Products Induce Interleukin-4 (IL-4)+ IL-10+ CD4+ T Cell Responses and Suppress Pathology in a Mouse Model of Colitis. Infect Immun. 2013;81(6):2104-11. doi:10.1128/IAI.00563-12.

Doyen V, Corazza F, Nhu Thi H, Le Chi T, Truyens C, Nagant C, Tran Thi Mong H, Fils JF, Thi Ngoc Huynh P, Michel O. Hookworm Treatment Induces a Decrease of Suppressive Regulatory T Cell Associated With a Th2 Inflammatory Response. PLoS One. 2021;16(6):e0252921. doi:10.1371/journal.pone.0252921.

Decrease Inflammation to Viruses Loukas A, Hotez PJ, Diemert D, Yazdanbakhsh M, McCarthy JS, Correa-Oliveira R, Croese J, Bethony JM. Hookworm Infection. Nat Rev Dis Primers. 2016;2:16088. doi:10.1038/nrdp.2016.88.

Buitrago G, Pickering DA, Cormack L, Ho H, Douglas L, Loukas A, Field MA. Suppression of Inflammation and Tissue Damage by a Hookworm Recombinant Protein in Experimental Colitis. Clin Transl Immunol. 2017;6(10):e157. doi:10.1038/cti.2017.42. PMC5671989.